DSpace Repository
Mutation EthAW21R confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv
- DSpace Home
- →
- Journal Articles
- →
- Articles: Department of Biological Sciences
- →
- View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.
| dc.contributor.author | Mugweru, Julius | |
| dc.contributor.author | Liu, Jianxiong | |
| dc.contributor.author | Makafe, Gaelle | |
| dc.contributor.author | Chiwala, Gift | |
| dc.contributor.author | Wang, Bangxing | |
| dc.contributor.author | Wang, Changwei | |
| dc.contributor.author | Li, Xinjie | |
| dc.contributor.author | Tan, Yaoju | |
| dc.contributor.author | Yew, Wing Wai | |
| dc.contributor.author | Tan, Shouyong | |
| dc.contributor.author | Zhang, Tianyu | |
| dc.date.accessioned | 2018-06-13T12:57:03Z | |
| dc.date.available | 2018-06-13T12:57:03Z | |
| dc.date.issued | 2018-06 | |
| dc.identifier.citation | Infection and Drug Resistance 2018:11 891–894 | en_US |
| dc.identifier.uri | http://hdl.handle.net/123456789/1527 | |
| dc.description.abstract | Ethionamide (ETA) and prothionamide (PRO) are interchangeably used in tuberculosis (TB) chemotherapy regimens. Subtle discrepancies between biochemical and genetic information on the modes of sensitivity and resistance of isoniazid (INH) and ETA warrants further studies. We report a new mutation – EthAW21R – in Mycobacterium bovis Bacillus Calmette-Guérin that corresponds with co-resistance to both PRO and ETA, which to the best of our knowledge has not been reported before. Our findings suggest that mutation EthAW21R could be used as a marker site for testing PRO and ETA cross-resistance | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Dove Press | en_US |
| dc.subject | mutation | en_US |
| dc.subject | EthAW21R | en_US |
| dc.subject | isoniazid | en_US |
| dc.subject | co-resistance | en_US |
| dc.subject | thioamides | en_US |
| dc.subject | molecular marker | en_US |
| dc.title | Mutation EthAW21R confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv | en_US |
| dc.type | Article | en_US |
Files in this item
This item appears in the following Collection(s)
-
Articles: Department of Biological Sciences
Journal articles for Biological Sciences