DSpace Repository

Mutation EthAW21R confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv

Mutation EthAW21R confers co-resistance to prothionamide and ethionamide in both Mycobacterium bovis BCG and Mycobacterium tuberculosis H37Rv

Mugweru, Julius; Liu, Jianxiong; Makafe, Gaelle; Chiwala, Gift; Wang, Bangxing; Wang, Changwei; Li, Xinjie; Tan, Yaoju; Yew, Wing Wai; Tan, Shouyong; Zhang, Tianyu
URI: http://hdl.handle.net/123456789/1527
Date: 2018-06

Abstract:

Ethionamide (ETA) and prothionamide (PRO) are interchangeably used in tuberculosis (TB) chemotherapy regimens. Subtle discrepancies between biochemical and genetic information on the modes of sensitivity and resistance of isoniazid (INH) and ETA warrants further studies. We report a new mutation – EthAW21R – in Mycobacterium bovis Bacillus Calmette-Guérin that corresponds with co-resistance to both PRO and ETA, which to the best of our knowledge has not been reported before. Our findings suggest that mutation EthAW21R could be used as a marker site for testing PRO and ETA cross-resistance

Show full item record

Files in this item

Thumbnail
Name: Mugweru et al 2018.pdf
Size: 617.5Kb
Format: PDF
Description: Full text
View/Open

This item appears in the following Collection(s)

Search DSpace


Browse

My Account