In vitro antiplasmodial activity of some plants used in Kisii, Kenya against Malaria and their chloroquine potentiative effects.

Muregi, F.W.; Chhabra, S.C.; Njagi, Eliud N.; Lang’at-Thoruwa, C.; Njue, Wilson N.; Ndiege, I.O.

dc.contributor.author	Muregi, F.W.
dc.contributor.author	Chhabra, S.C.
dc.contributor.author	Njagi, Eliud N.
dc.contributor.author	Lang’at-Thoruwa, C.
dc.contributor.author	Njue, Wilson N.
dc.contributor.author	Ndiege, I.O.
dc.date.accessioned	2015-07-27T11:22:59Z
dc.date.available	2015-07-27T11:22:59Z
dc.date.issued	2003
dc.identifier.citation	Journal of Ethnopharmacology 84 235 - 239	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/332
dc.description.abstract	Fifty-five organic and aqueous extracts of 11 plants used in malaria therapy in Kisii District, Kenya were tested in vitro against chloroquine (CQ)-sensitive and resistant strains of Plasmodium falciparum. Of the plants tested, 73% were active (IC(50) < 100 microg/ml). Three plants, Vernonia lasiopus, Rhamnus prinoides and Ficus sur afforded extracts with IC(50) values ranging less than 30 microg/ml against both CQ-sensitive and resistant strains. Combination of some extracts with CQ against the multi-drug resistant P. falciparum isolate V1/S revealed some synergistic effect. The plant extracts with low IC(50) values may be used as sources for novel antimalarial compounds to be used alone or in combination with CQ.	en_US
dc.language.iso	en	en_US
dc.title	In vitro antiplasmodial activity of some plants used in Kisii, Kenya against Malaria and their chloroquine potentiative effects.	en_US
dc.type	Article	en_US