Abstract:
Titania nano particles were synthesized at carbon paste electrode by cyclic voltammetry and then it was employed for
the determination of acetaminophen in phosphate buffer at pH 7.4. Carbon paste electrode with titania nano particle
displayed excellent electrochemically catalytic activities by shifting the oxidation potential of acetaminophen towards
the negative side. The mass transfer process at electrochemical interface was diffusion controlled. Electrochemical techniques
such as, electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization methods were used to
measure the resistance of the electrodes. The resistance of the titanium electrode decreased in two orders when compared
to the bare carbon paste electrode; the decrease in the resistance of the electrode and increase in the surface area
of the electrode are responsible for the negative shifting of the oxidation potential of acetaminophen. The present
method was applied to the determination of actetaminophen in paracetamol tablet, urine and blood sample by using
standard addition method and the obtained results were satisfactory with a good recovery of 98%.
