Abstract:
Background: To determine the effect of high dose tranexamic acid in decreasing
immediate postoperative bleeding in children less than ten kilo body
weight after complex cardiac surgery and also to evaluate the safety of high
dose in small children. Methods: Between January-December 2015, 25 children
weighing less than ten kilogram body weight underwent complex cardiac
surgery for cyanotic congenital heart disease. All children were given dose of
100 mg/kg tranexamic acid at the time of anaesthetic induction and also 100
mg/kg into the CPB prime. The Median age and weight was 80 days (3 - 365)
and 4.69 kg (2.4 - 7.8) respectively. The Median preoperative Hb was 10 g/dl
(9.6 - 19.5 g/dl). Cardiac surgery included total intracardiac repair for TOF in
10 pts (40%), TAPVC repair in 6 (24%), arterial switch operation in 6 pts
(24%), BD glenn in 1, repair of DORV with VSD in 1 and VSD closure with
scimitar vein reimplantation in 1 pt. Median CPB time was 127 minutes (97 -
343) and cross clamp time was 99 (67 - 200) minutes. Moderate to deep hypothermia
was maintained in all with median temperature of 24˚C (18 - 32).
Three children (12%) had elective open chest in view of anticipated bleeding.
Results: The Median postoperative drainage was 127 ml, (range 10 - 1250 ml).
The median postoperative use of whole blood was 95 ml (range 10 - 275),
packed cell was 187 ml (range 50 - 400 ml), frozen plasma was 88 ml (range 30
- 170), platelet concentrate was 57 ml, (range 10 - 100 ml) and cryoprecipitate
was median 47.5 ml, (range 30 - 80 ml). No neurological dysfunction and renal
dysfunction has been observed in any of the pts. Out of 4 mortalities (16%),only one was attributed to bleeding (4%) due to usage of ECMO. No late neurological
or renal dysfunction has been observed in remaining 21 pts on follow
up. Conclusion: High dose Tranexamic acid can be safely used in small
children during complex cardiac surgery with significant reduction in postoperative
bleeding and blood product usage without any higher incidence of
neurological, renal dysfunction or myocardial infarction
