Effect of SP600125 on proliferation of embryonic stem cell

dc.contributor.author	Zhou, Yonghua
dc.contributor.author	Jiang, Minggui
dc.contributor.author	Wang, Mei
dc.contributor.author	Luo, Chao
dc.contributor.author	Wang, Zili
dc.contributor.author	Wen, Sheng
dc.contributor.author	Liu, Wenbin
dc.contributor.author	Xiao, Yamei
dc.date.accessioned	2016-10-25T13:58:19Z
dc.date.available	2016-10-25T13:58:19Z
dc.date.issued	2013-04
dc.identifier.citation	American Journal of Molecular Biology, 2013, 3, 67-71	en_US
dc.identifier.uri	http://dx.doi.org/10.4236/ajmb.2013.32009
dc.identifier.uri	http://hdl.handle.net/123456789/1034
dc.description.abstract	SP600125 is an inhibitor of c-Jun NH2-terminal kinase (JNK), which plays a fundamental role in regulating animal development. Using SP600125 to deal with the mouse embryonic stem cells, it is revealed that the number of the ESC colonies decreased and the size became smaller. With treatment by SP600125, the proliferation of mouse ES cells is seriously inhibited for the cycle arrested in the G2/M phase, and the effect of SP600125 on the ES cells displays correlation of dose and time. The obtained results indicate that JNK may be an important regulator in the progression of cell cycle at the G2/M cell phase for the ES cells.	en_US
dc.language.iso	en	en_US
dc.publisher	Scientific Research Publishing	en_US
dc.subject	JNK	en_US
dc.subject	SP600125	en_US
dc.subject	Embryonic Stem Cell	en_US
dc.subject	Cell Cycle	en_US
dc.title	Effect of SP600125 on proliferation of embryonic stem cell	en_US
dc.type	Article	en_US

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